Induction of SARS-CoV-2 Protein S-Specific CD8+ T Cells in the Lungs of gp96-Ig-S Vaccinated Mice

Given the aggressive spread of COVID-19-related deaths, there is an urgent public health need to support development vaccine candidates rapidly improve available control measures against SARS-CoV-2. To meet this need, we are leveraging our existing platform target Here, generated cellular heat shock chaperone protein, glycoprotein 96 (gp96), deliver SARS-CoV-2 protein S (spike) immune system and induce cell-mediated responses. We showed that effectively stimulates a robust response S. Moreover, confirmed gp96-Ig, secreted from allogeneic cells expressing full-length S, generates powerful, polyepitope-specific CD4+ CD8+ T cell responses in both lung interstitium airways. These findings were further strengthened by observation protein-S -specific induced human leukocyte antigen HLA-A2.1 transgenic mice thus providing encouraging translational data likely work humans, context presentation.